Intravenous theophylline is indicated as an adjunct to inhaled beta-2 selective agonists and systemically administered corticosteroids for the treatment of acute exacerbations of the symptoms and reversible airflow obstruction associated with asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.
From the U.S. FDA-approved label for Aminophylline. Full label: DailyMed.
Intravenous theophylline is indicated as an adjunct to inhaled beta-2 selective agonists and systemically administered corticosteroids for the treatment of acute exacerbations of the symptoms and reversible airflow obstruction associated with asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.
From the U.S. FDA-approved label for Aminophylline. Full label: DailyMed.
General Considerations: The steady-state serum theophylline concentration is a function of the infusion rate and the rate of theophylline clearance in the individual patient. Because of marked individual differences in the rate of theophylline clearance, the dose required to achieve a serum theophylline concentration in the 10-20 mcg/mL range varies fourfold among otherwise similar patients in the absence of factors known to alter theophylline clearance. For a given population there is no single theophylline dose that will provide both safe and effective serum concentrations for all patients.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Aminophylline is contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product including ethylenediamine.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
Concurrent Illness: Theophylline should be used with extreme caution in patients with the following clinical conditions due to the increased risk of exacerbation of the concurrent condition: Active peptic ulcer disease Seizure disorders Cardiac arrhythmias (not including bradyarrhythmias) Conditions That Reduce Theophylline Clearance: There are several readily identifiable causes of reduced theophylline clearance. If the infusion rate is not appropriately reduced in the presence of these risk factors, severe and potentially fatal theophylline toxicity can occur.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
Adverse reactions associated with theophylline are generally mild when peak serum theophylline concentrations are <20 mcg/mL and mainly consist of transient caffeine-like adverse effects such as nausea, vomiting, headache, and insomnia.
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
7 products from 6 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Aminophylline 25mg Injection | Aminophylline (25mg) | Hindusthan Pharmaceuticals Ltd. | |
| Aminophylin Injection | Aminophylline (NA) | Zydus Cadila | vial of 1 ml Injection |
| Aminophyllin 250mg Injection | Aminophylline (250mg) | Biostan Indian Pharmaceuticals | vial of 10 ml Injection |
| Aminophylline 250mg Injection | Aminophylline (25mg/ml) | Harson Laboratories | ampoule of 10 ml Injection |
| Biofylin 250mg Injection | Aminophylline (250mg) | Biostan Indian Pharmaceuticals | vial of 1 Injection |
| Imitrisin Injection | Aminophylline (125mg/ml) | RSM Kilitch Pharma Pvt Ltd | vial of 10 ml Injection |
| Renophyllline Injection | Aminophylline (25mg) | Rathi Laboratories (Hindustan) Pvt Ltd | ampoule of 10 ml Injection |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store at 20 to 25°C (68 to 77°F). PROTECT FROM LIGHT.
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
