Caffeine citrate injection and caffeine citrate oral solution are indicated for the short term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.
From the U.S. FDA-approved label for Caffeine citrate. Full label: DailyMed.
Caffeine citrate injection and caffeine citrate oral solution are indicated for the short term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.
From the U.S. FDA-approved label for Caffeine citrate. Full label: DailyMed.
Prior to initiation of caffeine citrate, baseline serum levels of caffeine should be measured in infants previously treated with theophylline, since preterm infants metabolize theophylline to caffeine. Likewise, baseline serum levels of caffeine should be measured in infants born to mothers who consumed caffeine prior to delivery, since caffeine readily crosses the placenta. The recommended loading dose and maintenance doses of caffeine citrate follow.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Caffeine citrate injection and caffeine citrate oral solution are contraindicated in patients who have demonstrated hypersensitivity to any of its components.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
During the double-blind, placebo-controlled clinical trial, six cases of necrotizing enterocolitis developed among the 85 infants studied (caffeine=46, placebo=39), with 3 cases resulting in death. Five of the six patients with necrotizing enterocolitis were randomized to or had been exposed to caffeine citrate. Reports in the published literature have raised a question regarding the possible association between the use of methylxanthines and development of necrotizing enterocolitis, although a causal relationship between methylxanthine use and necrotizing enterocolitis has not been established.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
Overall, the reported number of adverse events in the double-blind period of the controlled trial was similar for the caffeine citrate and placebo groups. The following table shows adverse events that occurred in the double-blind period of the controlled trial and that were more frequent in caffeine citrate-treated patients than placebo.
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
9 products from 6 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Apnicaf 20mg Injection | Caffeine (20mg) | Abbott India Ltd. | |
| Apnicaf Oral Solution | Caffeine | Abbott India Ltd. | |
| Apnicaf Injection | Caffeine (10mg) | Abbott | vial of 3 ml Injection |
| Cafirate Injection | Caffeine (20mg/ml) | Sun Pharmaceutical Industries Ltd | vial of 1 ml Injection |
| Cafirate Tablet | Caffeine (NA) | Sun Pharmaceutical Industries Ltd | strip of 10 tablets |
| Cafneon 40mg Injection | Caffeine (40mg) | Neon Laboratories Ltd | vial of 2 ml Injection |
| Capnea Injection | Caffeine (20mg/ml) | Cipla Ltd | vial of 1 ml Injection |
| Capnea Solution | Caffeine (20mg) | Cipla Ltd | bottle of 1 ml Oral Solution |
| Noapnea Injection | Caffeine (20mg/ml) | Delcure Life Sciences | vial of 1 ml Injection |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store at 20° to 25°C (68° to 77°F).
Storage information from the U.S. FDA-approved label.
Caffeine citrate is recorded in the NepalDoc medicine catalog for: Migraine, Mild stimulant of the central nervous system, Short-term treatment of neonatal apnoea of prematurity.
For Migraine: Flunarizine, Magnesium valproate.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
