Carvedilol

Take with food. Individualize dosage and monitor during up-titration. Heart failure: Start at 3.125 mg twice daily and increase to 6.25, 12.5, and then 25 mg twice daily over intervals of at least 2 weeks.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Bronchial asthma or related bronchospastic conditions. Second- or third-degree AV block. Sick sinus syndrome. Severe bradycardia (unless permanent pacemaker in place). Patients in cardiogenic shock or decompensated heart failure requiring the use of IV inotropic therapy. Severe hepatic impairment. History of serious hypersensitivity reaction (e.g., Stevens-Johnson syndrome, anaphylactic reaction, angioedema) to any component of this medication or other medications containing carvedilol.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Acute exacerbation of coronary artery disease upon cessation of therapy: Do not abruptly discontinue. Bradycardia, hypotension, worsening heart failure/fluid retention may occur. Reduce the dose as needed. Non-allergic bronchospasm (e.g., chronic bronchitis and emphysema): Avoid β-blockers. However, if deemed necessary, use with caution and at lowest effective dose. Diabetes: May mask symptoms of hypoglycemia and alter glucose levels; monitor 5.1 Cessation of Therapy Patients with coronary artery disease, who are being treated with carvedilol tablets, should be advised against abrupt discontinuation of therapy.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

Most common adverse events: Heart failure and left ventricular dysfunction following myocardial infarction (≥10%): Dizziness, fatigue, hypotension, diarrhea, hyperglycemia, asthenia, bradycardia, weight increase. Hypertension (≥5%): Dizziness. To report SUSPECTED ADVERSE REACTIONS, contact Zydus Pharmaceuticals (USA) Inc. at 1- 877-993-8779 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

192 products from 75 makers in the NepalDoc medicine catalog use this generic:

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Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Storage Store at 20°C to 25°C (68°F to 77°F). Protect from moisture.

Storage information from the U.S. FDA-approved label.