Colistimethate sodium

Important Colistimethate for Injection, USP is supplied in vials containing colistimethate sodium equivalent to 150 mg colistin base activity per vial. Reconstitution for Intravenous or Intramuscular Administration The 150 mg vial should be reconstituted with 2 mL Sterile Water for Injection, USP. The reconstituted solution provides colistimethate sodium at a concentration equivalent to 75 mg/mL colistin base activity.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

The use of Colistimethate for Injection, USP is contraindicated for patients with a history of sensitivity to the drug or any of its components.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Maximum daily dose calculated from colistin base activity should not exceed 5 mg/kg/day with normal renal function. Transient neurological disturbances may occur. These include circumoral paresthesia or numbness, tingling or formication of the extremities, generalized pruritus, vertigo, dizziness, and slurring of speech. For these reasons, patients should be warned not to drive vehicles or use hazardous machinery while on therapy. Reduction of dosage may alleviate symptoms. Therapy need not be discontinued, but such patients should be observed with particular care.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The following adverse reactions have been reported: Gastrointestinal - gastrointestinal upset Nervous System - tingling of extremities and tongue, slurred speech, dizziness, vertigo, paresthesia, and seizures Integumentary - generalized itching, urticaria and rash Body as a Whole - fever and anaphylaxis Laboratory Deviations - increased blood urea nitrogen (BUN), elevated creatinine and decreased creatinine clearance…

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

164 products from 76 makers in the NepalDoc medicine catalog use this generic:

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Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Store unreconstituted product between 20º to 25ºC (68º to 77ºF) (see USP Controlled Room Temperature). Store reconstituted solution in refrigerator 2º to 8ºC (36º to 46ºF) or between 20º to 25ºC (68º to 77ºF) and use within 7 days.

Storage information from the U.S. FDA-approved label.