Cycloserine is indicated in the treatment of active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible to this drug and when treatment with the primary medications (streptomycin, isoniazid, rifampin, and ethambutol) has proved inadequate. Like all antituberculosis drugs, cycloserine should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent.
From the U.S. FDA-approved label for Cycloserine. Full label: DailyMed.
Cycloserine is indicated in the treatment of active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible to this drug and when treatment with the primary medications (streptomycin, isoniazid, rifampin, and ethambutol) has proved inadequate. Like all antituberculosis drugs, cycloserine should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent. Cycloserine may be effective in the treatment of acute urinary tract infections caused by susceptible strains of gram-positive and gram- negative bacteria. Use of cycloserine in these infections should be considered only when more conventional therapy has failed and when the organism has been demonstrated to be susceptible to the drug.
From the U.S. FDA-approved label for Cycloserine. Full label: DailyMed.
Cycloserine is effective orally and is currently administered only by this route. The usual dosage is 500 mg to 1 g daily in divided doses monitored by blood levels. 1 The initial adult dosage most frequently given is 250 mg twice daily at 12-hour intervals for the first 2 weeks.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Administration is contraindicated in patients with any of the following: Hypersensitivity to cycloserine, Epilepsy, Depression, severe anxiety, or psychosis, Severe renal insufficiency, Excessive concurrent use of alcoho
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
Administration of cycloserine should be discontinued or the dosage reduced if the patient develops allergic dermatitis or symptoms of CNS toxicity, such as convulsions, psychosis, somnolence, depression, confusion, hyperreflexia, headache, tremor, vertigo paresis, or dysarthria. The toxicity of cycloserine is closely related to excessive blood levels (above 30 mcg/mL), as determined by high dosage or inadequate renal clearance. The ratio of toxic dose to effective dose in tuberculosis is small. The risk of convulsions is increased in chronic alcoholics.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
Most adverse reactions occurring during therapy with cycloserine involve the nervous system or are manifestations of drug hypersensitivity.
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
8 products from 7 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| CYCLOKOX 250MG CAPSULE | Cycloserine (250mg) | Radicura Pharma pvt ltd | strip of 10 capsules |
| Cyclorin Capsule | Cycloserine (250mg) | Lupin Ltd | strip of 6 capsules |
| Cyclorine Capsule | Cycloserine (250mg) | Lupin Ltd | strip of 6 capsules |
| Cyclotec 250mg Capsule | Cycloserine (250mg) | United Biotech Pvt Ltd | strip of 10 capsules |
| Cyserin 250mg Capsule | Cycloserine (250mg) | Neon Laboratories Ltd | strip of 10 capsules |
| MD Serine 250mg Tablet | Cycloserine (250mg) | Maneesh Pharmaceuticals Ltd | strip of 4 tablets |
| Mycotuf C 250mg Tablet | Cycloserine (250mg) | Cadila Pharmaceuticals Ltd | strip of 10 tablets |
| Novaserine 250mg Capsule | Cycloserine (250mg) | Pharmasynth Formulations Ltd | strip of 6 capsules |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store at controlled room temperature, 20° to 25°C (68° to 77°F).
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
