Dactinomycin for Injection is an actinomycin indicated for the treatment of: adult and pediatric patients with Wilms tumor, as part of a multi-phase, combination chemotherapy regimen. adult and pediatric patients with rhabdomyosarcoma, as part of a multi-phase, combination chemotherapy regimen.
From the U.S. FDA-approved label for Dactinomycin. Full label: DailyMed.
Dactinomycin for Injection is an actinomycin indicated for the treatment of: adult and pediatric patients with Wilms tumor, as part of a multi-phase, combination chemotherapy regimen. adult and pediatric patients with rhabdomyosarcoma, as part of a multi-phase, combination chemotherapy regimen. post-menarchal patients with gestational trophoblastic neoplasia, as a single agent or as part of a combination chemotherapy regimen. adult patients with locally recurrent or locoregional solid malignancies, as a component of palliative or adjunctive regional perfusion.
From the U.S. FDA-approved label for Dactinomycin. Full label: DailyMed.
Wilms Tumor: The recommended dose is 45 mcg/kg intravenously once every 3 to 6 weeks for up to 26 weeks, as part of a multi-agent combination chemotherapy regimen. Rhabdomyosarcoma: The recommended dose is 15 mcg/kg intravenously once daily for 5 days every 3 to 9 weeks for up to 112 weeks, as part of a multi-agent combination chemotherapy regimen. Ewing Sarcoma: The recommended dose is 1,250 mcg/m 2 intravenously once every 3 weeks for 51 weeks, as part of a multi-agent combination chemotherapy regimen.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Secondary Malignancy or Leukemia: Increased risk of secondary malignancies following treatment. Veno-occlusive Disease: Can cause severe or fatal VOD. Monitor for elevations in AST, ALT, total bilirubin, hepatomegaly, weight gain, or ascites. Consider delaying next dose. Extravasation: Immediately interrupt the injection or infusion and apply ice. Myelosuppression: Monitor blood cell counts before each cycle. Delay next dose if severe myelosuppression has not improved. Immunizations: Vaccination with live viral vaccines is not recommended before or during treatment.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
The following serious adverse reactions are described elsewhere in the labeling: Secondary Malignancy and Leukemia Veno-occlusive Disease Extravasation Myelosuppression Immunizations Severe Mucocutaneous Reactions Renal Toxicity Hepatotoxicity Potentiation of Radiation Toxicity and Radiation Recall Common adverse reactions are: infection, alopecia, rash, dysphagia, fatigue, fever, nausea, vomiting, anemia, neutropenia,…
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
7 products from 7 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Tinowel Injection | Dactinomycin | Getwell Pharmaceuticals | |
| Actinocin 0.5mg Injection | Dactinomycin (0.5mg) | Neon Laboratories Ltd | vial of 1 Injection |
| Cosmegen 0.5mg Injection | Dactinomycin (0.5mg) | Wockhardt Ltd | vial of 1 ml Injection |
| Dacmozen 0.5mg Injection | Dactinomycin (0.5mg) | Vhb Life Sciences Inc | vial of 2 ml Injection |
| Dactino 0.5mg Injection | Dactinomycin (0.5mg/2ml) | Chandra Bhagat Pharma Pvt Ltd | vial of 1 Injection |
| Dactinoget 0.5mg Injection | Dactinomycin (0.5mg) | GLS Pharma Ltd. | vial of 1 Powder for Injection |
| Tinowel 0.5mg Injection | Dactinomycin (0.5mg) | Getwell Oncology Pvt Ltd | vial of 1 Injection |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Conditions Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F). Protect from light and humidity. Store the reconstituted Dactinomycin for Injection, USP at room temperature for no more than 4 hours from reconstitution to completion of administration. Dactinomycin for Injection, USP is a cytotoxic drug.
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
