Diltiazem

Hypertensive or anginal patients who are treated with other formulations of diltiazem can safely be switched to diltiazem hydrochloride extended-release capsules at the nearest equivalent total daily dose. Subsequent titration to higher or lower doses may, however, be necessary and should be initiated as clinically indicated. Studies have shown a slight increase in the rate of absorption of diltiazem hydrochloride extended-release capsules when ingested with a high-fat breakfast; therefore, administration in the morning on an empty stomach is recommended.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Diltiazem hydrochloride is contraindicated in: patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker; patients with second or third degree AV block except in the presence of a functioning ventricular pacemaker; patients with hypotension (less than 90 mmHg systolic); patients who have demonstrated hypersensitivity to the drug; and patients with acute myocardial infarction and pulmonary congestion as documented by X-ray on admission.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Cardiac Conduction Diltiazem hydrochloride prolongs AV node refractory periods without significantly prolonging sinus node recovery time, except in patients with sick sinus syndrome. This effect may rarely result in abnormally slow heart rates (particularly in patients with sick sinus syndrome) or second, or third degree AV block (22 of 10,119 patients, or 0.2%); 41% of these 22 patients were receiving concomitant β-adrenoceptor antagonists versus 17% of the total group. Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

Serious adverse reactions to diltiazem hydrochloride have been rare in studies with other formulations, as well as with diltiazem hydrochloride extended-release capsules. It should be recognized, however, that patients with impaired ventricular function and cardiac conduction abnormalities have usually been excluded from these studies.

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

136 products from 65 makers in the NepalDoc medicine catalog use this generic:

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Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Store at 20° to 25°C (68° to 77°F); Keep tightly closed. Keep out of the reach of children.

Storage information from the U.S. FDA-approved label.