Hydroxyurea (hydroxycarbamide)

Initial dose: 15 mg/kg orally once daily. Monitor the patient’s blood count every two weeks. The dose may be increased by 5 mg/kg/day every 8 to 12 weeks until a maximum tolerated dose or 35 mg/kg/day is reached if blood counts are in an acceptable range.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

XROMI is contraindicated in patients: who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation.. In patients who have demonstrated a previous hypersensitivity to hydroxyurea or any other component of its formulation.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Hemolytic anemia: Monitor blood counts throughout treatment. If hemolysis persists, discontinue XROMI. Embryo-Fetal toxicity: Can cause fetal harm. Advise of potential risk to a fetus and use of effective contraception. Vasculitic toxicities: Institute treatment and discontinue XROMI if this occurs. Live Vaccinations: Avoid live vaccine use in a patient taking XROMI. Risks with concomitant use of antiretroviral drugs: Pancreatitis, hepatotoxicity, and neuropathy have occurred. Monitor for signs and symptoms in patients with HIV infection using antiretroviral drugs; discontinue XROMI and implement treatment.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The following clinically significant adverse reactions are described in detail in other labeling sections: Myelosuppression Hemolytic anemia Malignancies Vasculitic toxicities Live vaccinations Macrocytosis Pulmonary toxicity Most common adverse reactions (incidence > 5%) are neutropenia and thrombocytopenia, and popular rash. To report SUSPECTED ADVERSE REACTIONS, contact Rare Disease Therapeutics, Inc.

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

28 products from 25 makers in the NepalDoc medicine catalog use this generic:

Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

16.2 Storage Store XROMI between 2°C to 8°C (35°F to 46°F) excursions permitted to 25°C (77°F) for up to 72 hours. Keep the bottle tightly closed to protect the integrity of the product and minimize the risk of accidental spillage. Do not freeze. Use within 12 weeks after initially opening the bottle. Discard unused XROMI remaining after 12 weeks of first opening the bottle.

Storage information from the U.S. FDA-approved label.