Isoniazid Tablets are recommended for all forms of tuberculosis in which organisms are susceptible. However, active tuberculosis must be treated with multiple concomitant anti-tuberculosis medications to prevent the emergence of drug resistance.
From the U.S. FDA-approved label for Isoniazid. Full label: DailyMed.
Isoniazid Tablets are recommended for all forms of tuberculosis in which organisms are susceptible. However, active tuberculosis must be treated with multiple concomitant anti-tuberculosis medications to prevent the emergence of drug resistance. Single-drug treatment of active tuberculosis with isoniazid or any other medication, is inadequate therapy. Isoniazid Tablets are recommended as preventive therapy for the following groups, regardless of age. (Note: the criterion for a positive reaction to a skin test (in millimeters of induration) for each group is given in parenthesis): Persons with human immunodeficiency virus (HIV) infection (greater than or equal to 5 mm) and persons with risk factors for HIV infection whose HIV infection status is unknown but who are suspected of having HIV infection. Preventive therapy may be considered for HIV infected persons who are tuberculin-negative but belong to groups in which the prevalence of tuberculosis infection is high.
From the U.S. FDA-approved label for Isoniazid. Full label: DailyMed.
(See also INDICATIONS AND USAGE ) NOTE For preventive therapy of tuberculous infection and treatment of tuberculosis, it is recommended that physicians be familiar with the following publications: the recommendations of the Advisory Council for the Elimination of Tuberculosis, published in the MMWR: vol 42; RR-4, 1993 and Treatment of Tuberculosis and Tuberculosis Infection in Adults and Children, American Journal of Respiratory and Critical Care Medicine: vol 149; 1359-1374, 1994. For Treatment of Tuberculosis Isoniazid is used in conjunction with other effective anti-tuberculous agents.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Isoniazid is contraindicated in patients who develop severe hypersensitivity reactions, including drug- induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
See the boxed warning. Severe Cutaneous Adverse Reactions Severe cutaneous adverse reactions (SCARs) including toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) have been reported with the use of isoniazid (see ADVERSE REACTIONS ). Symptoms can be serious and potentially life threatening. If symptoms or signs of SCARs develop, discontinue isoniazid immediately and institute appropriate therapy.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
The most frequent reactions are those affecting the nervous system and the liver. Nervous System Reactions Peripheral neuropathy is the most common toxic effect. It is dose-related, occurs most often in the malnourished and in those predisposed to neuritis (e.g., alcoholics and diabetics) and is usually preceded by paresthesias of the feet and hands. The incidence is higher in "slow inactivators".
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
9 products from 8 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Isonex 100mg Tablet | Isoniazid (100mg) | Pfizer Ltd. | |
| Rinizide 300 300mg Tablet | Isoniazid (300mg) | Lupin Ltd. | |
| Solonex 300mg Tablet | Isoniazid (300mg) | Macleods Pharmaceuticals Pvt. Ltd. | |
| Isonex 300mg Tablet | Isoniazid (300mg) | Pfizer Ltd | strip of 10 tablets |
| Isoniazid 300mg Tablet | Isoniazid (300mg) | Cadila Pharmaceuticals Ltd | strip of 10 tablets |
| Isonij 300mg Tablet | Isoniazid (300mg) | Sunij Pharma Pvt Ltd | strip of 10 tablets |
| Lup Inh 300mg Tablet | Isoniazid (300mg) | Lupin Ltd | strip of 10 tablets |
| Solonex DT Tablet | Isoniazid (100mg) | Macleods Pharmaceuticals Pvt Ltd | strip of 10 tablet dt |
| Solonex Tablet | Isoniazid (300mg) | Macleods Pharmaceuticals Pvt Ltd | strip of 10 tablets |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Storage Store at 20° to 25°C (68° to 77°F). Protect from moisture and light.
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
