For the prevention and treatment of portal-systemic encephalopathy, including the stages of hepatic pre-coma and coma. Controlled studies have shown that lactulose solution therapy reduces the blood ammonia levels by 25 to 50%; this is generally paralleled by an improvement in the patients' mental state and by an improvement in EEG patterns.
From the U.S. FDA-approved label for Lactulose. Full label: DailyMed.
For the prevention and treatment of portal-systemic encephalopathy, including the stages of hepatic pre-coma and coma. Controlled studies have shown that lactulose solution therapy reduces the blood ammonia levels by 25 to 50%; this is generally paralleled by an improvement in the patients' mental state and by an improvement in EEG patterns. The clinical response has been observed in about 75% of patients, which is at least as satisfactory as that resulting from neomycin therapy. An increase in patients' protein tolerance is also frequently observed with lactulose solution therapy. In the treatment of chronic portal-systemic encephalopathy, lactulose solution has been given for over 2 years in controlled studies.
From the U.S. FDA-approved label for Lactulose. Full label: DailyMed.
Oral Adult The usual adult oral dosage is 2 to 3 tablespoonfuls (30 to 45 mL, containing 20 g to 30 g of Generlac Solution) three or four times daily. The dosage may be adjusted every day or two to produce 2 or 3 soft stools daily. Hourly doses of 30 to 45 mL of Generlac Solution may be used to induce the rapid laxation indicated in the initial phase of the therapy of portal-systemic encephalopathy.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Since Generlac Solution (Lactulose Solution, USP) contains galactose (less than 1.6 g/15 mL), it is contraindicated in patients who require a low galactose diet.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
A theoretical hazard may exist for patients being treated with lactulose solution who may be required to undergo electrocautery procedures during proctoscopy or colonoscopy. Accumulation of H 2 gas in significant concentration in the presence of an electrical spark may result in an explosive reaction. Although this complication has not been reported with lactulose, patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution. Insufflation of CO 2 as an additional safeguard may be pursued but is considered to be a redundant measure.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
Precise frequency data are not available. Generlac Solution may produce gaseous distention with flatulence or belching and abdominal discomfort such as cramping in about 20% of patients. Excessive dosage can lead to diarrhea with potential complications such as loss of fluids, hypokalemia, and hypernatremia. Nausea and vomiting have been reported.
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
281 products from 246 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Duphalac 150ml Oral Solution | Lactulose (150ml) | Abbott India Ltd. | |
| Duphalac 200ml Syrup | Lactulose (200ml) | Abbott India Ltd. | |
| Duphalac 250ml Syrup | Lactulose (250ml) | Abbott India Ltd. | |
| Duphalac 450ml Syrup | Lactulose (450ml) | Abbott India Ltd. | |
| Evalax 100ml Syrup | Lactulose (100ml) | OHM Pharmaceuticals Lab Pvt. Ltd. | |
| Evalax 200ml Syrup | Lactulose (200ml) | OHM Pharmaceuticals Lab Pvt. Ltd. | |
| Evict 100 Suspension | Lactulose | A.D. Pharmaceuticals | |
| Evict 180ml Syrup | Lactulose (180ml) | Albert David Ltd. | |
| Evict 90ml Syrup | Lactulose (90ml) | Albert David Ltd. | |
| Gyroxil 200ml Syrup | Lactulose (200ml) | National Healthcare Pvt. Ltd. | |
| Laclose Solution | Lactulose | S.R. Drug Laboratories Pvt. Ltd. | |
| Laculax 100ML Syrup | Lactulose (100ML) | Lomus Pharmaceutical Pvt. Ltd. | |
| Laculax 200ml Syrup | Lactulose (200ml) | Lomus Pharmaceutical Pvt. Ltd. | |
| Laxil 100ml Solution | Lactulose (100ml) | Mapra Laboratories Pvt Ltd. | |
| Laxil 200 ml Syrup | Lactulose (200 ml) | Mapra Laboratories Pvt Ltd. | |
| Laxopeg 100ML Syrup | Lactulose (100ML) | Fourrts India Laboratories Pvt Ltd | |
| Laxopeg 200ml Syrup | Lactulose (200ml) | Fourrts India Laboratories Pvt Ltd | |
| Livoluk 100ml,200ml,450ml Syrup | Lactulose (100ml,200ml,450ml) | Panacea Biotec Ltd. | |
| Osmolax 100ml,200ml Syrup | Lactulose (100ml,200ml) | Square Pharmaceuticals Ltd. | |
| Osmowin 200ML, 100ML Syrup | Lactulose (200ML, 100ML) | Win-Medicare Pvt. Ltd. | |
| SERELOSE 100ML Solutions | Lactulose (100ML) | Beximco Pharmaceuticals Ltd. | |
| Smulax 100ml,200ml Liquid | Lactulose (100ml,200ml) | Aristo Pharmaceuticals Ltd. | |
| SWIFTOLAC 150ML Syrup | Lactulose (150ML) | Shreya Life Sciences Pvt Ltd | |
| SWIFTOLAC 200ML Capsule | Lactulose (200ML) | Shreya Life Sciences Pvt Ltd | |
| SWIFTOLAC 200ML Syrup | Lactulose (200ML) | Shreya Life Sciences Pvt Ltd | |
| Abloz Oral Solution | Lactulose (10gm/15ml) | Roseate Medicare | bottle of 200 ml Oral Solution |
| Actolax 10gm Syrup | Lactulose (10gm/15ml) | In Med Therapeutics | bottle of 200 ml Syrup |
| Actual Syrup | Lactulose (100mg) | Biosans Lifecare | bottle of 100 ml Syrup |
| Aden Loose UP 10gm Oral Solution | Lactulose (10gm) | Adenscot Healthcare | bottle of 100 ml Oral Solution |
| Adzolex-Plus Oral Solution | Lactulose (10gm/15ml) | ADZO Lifesciences Pvt Ltd | bottle of 200 ml Oral Solution |
Showing 30 of 281 catalog products. Search the full catalog in the app.
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store at 20° to 25°C (68° to 77°F). Storage conditions, a normal darkening of color may occur.
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
