Leflunomide

Loading dosage for patients at low risk for leflunomide -associated hepatotoxicity and leflunomide -associated myelosuppression: 100 mg daily for 3 days. Maintenance dosage: 20 mg daily. Maximum recommended daily dosage: 20 mg once daily.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Leflunomide tablets are contraindicated in: Pregnant women. Leflunomide may cause fetal harm. If a woman becomes pregnant while taking this drug, stop leflunomide, apprise the patient of the potential hazard to the fetus, and begin a drug elimination procedure. Patients with severe hepatic impairment. Patients with known hypersensitivity to leflunomide or any of the other components of leflunomide tablets. Known reactions include anaphylaxis. Patients being treated with teriflunomide. Severe hepatic impairment.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

After stopping leflunomide, it is recommended that an accelerated drug elimination procedure be used to reduce the plasma concentrations of the active metabolite, teriflunomide. Severe infections (including sepsis), pancytopenia, agranulocytosis and thrombocytopenia: Stop leflunomide and use accelerated elimination procedure. Do not start leflunomide in patients with active infection. Monitor CBCs during treatment with leflunomide. Stevens-Johnson syndrome and toxic epidermal necrolysis: Stop leflunomide and use accelerated elimination procedure.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The following serious adverse reactions are described elsewhere in the labeling: Hepatotoxicity Immunosuppression Bone marrow suppression Stevens-Johnson syndrome and toxic epidermal necrolysis Peripheral neuropathy Interstitial lung disease The most commonly reported adverse reactions (≥10%) regardless of relation to leflunomide treatment were diarrhea, respiratory infection, nausea, headache, rash, abnormal liver enzymes,…

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

87 products from 48 makers in the NepalDoc medicine catalog use this generic:

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Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Store at 25°C (77°F); Protect from light.

Storage information from the U.S. FDA-approved label.