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Methotrexate

Folate analog metabolic inhibitor
Powder · Injection · Tablet15 mg · 50 mg · 2.5 mg · 5 mg180 brands · 68 makers
Methotrexate is a folate analog metabolic inhibitor used for the following neoplastic diseases for the: o. Methotrexate is listed in Nepal's National List of Essential Medicines (NLEM, Sixth Revision 2021) under Immunomodulators, Antineoplastic and Medicines used in Palliative Care.
Generic namemethotrexate
Therapeutic classImmunomodulators, Antineoplastic and Medicines used in Palliative Care > 8.2.1 Cytotoxic medicines (complementary list)
Therapeutic classMedicines for Diseases of Joints > 29.2 Disease modifying agents used in rheumatic disorders (DMARDs)
Form & strength (NLEM)Powder for injection: 15 mg, 50 mg (as sodium salt) in vial; Tablet: 2.5 mg, 5 mg, 10 mg (as sodium salt)
Form & strength (NLEM)Tablet: 2.5 mg, 5 mg, 10 mg (as sodium salt)
Source / स्रोतNational List of Essential Medicines Nepal (2021); NepalDoc medicine catalog

What it's for

Methotrexate Injection is a folate analog metabolic inhibitor indicated for: The following neoplastic diseases for the: o Treatment of adult and pediatric patients with acute lymphoblastic leukemia as part of a combination chemotherapy regimen. o Prophylaxis and treatment of adult and pediatric patients with meningeal leukemia.

From the U.S. FDA-approved label for Methotrexate. Full label: DailyMed.

Methotrexate Injection is a folate analog metabolic inhibitor indicated for: The following neoplastic diseases for the: o Treatment of adult and pediatric patients with acute lymphoblastic leukemia as part of a combination chemotherapy regimen. o Prophylaxis and treatment of adult and pediatric patients with meningeal leukemia. o Treatment of adult and pediatric patients with osteosarcoma as part of a combination chemotherapy regimen. o Treatment of adults with squamous cell carcinoma of the head and neck as a single agent.

From the U.S. FDA-approved label for Methotrexate. Full label: DailyMed.

Verify pregnancy status in females of reproductive potential before starting Methotrexate Injection., Neoplastic diseases: Refer to the prescribing information for disease specific dosing recommendations.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Methotrexate Injection is contraindicated in: Patients with history of severe hypersensitivity to methotrexate., Pregnancy in patients with non-neoplastic diseases., History of severe hypersensitivity to methotrexate., Pregnancy: in patients with non-neoplastic diseases.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Secondary malignancies can occur., Tumor lysis syndrome can occur in patients with rapidly growing tumors., Immunizations and Risks associated with Live Vaccines: Immunizations may be ineffective. Live vaccines are not recommended due to risk of disseminated infection., Infertility: Can cause impairment of fertility, oligospermia, and menstrual dysfunction. 5.1 Embryo-Fetal Toxicity Based on published reports and its mechanism of action, methotrexate can cause embryo-fetal toxicity, including fetal death when administered to a pregnant woman.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The following adverse reactions are described, or described in greater detail, in other sections: Hypersensitivity Reactions, Myelosuppression, Serious Infections, Renal Toxicity, Hepatotoxicity, Neurotoxicity, Gastrointestinal Toxicity, Pulmonary Toxicity, Dermatologic Reactions, Secondary Malignancies, Tumor Lysis Syndrome, Increased Risk of Adverse Reactions due to Third-Space Accumulation Common adverse reactions include…

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

180 products from 68 makers in the NepalDoc medicine catalog use this generic:

BrandCompositionMakerPack
Biotrexate 2.5mg TabletMethotrexate (2.5mg)Biochem Pharmaceuticals Industries Limited.
C-Methocel 50mg InjectionMethotrexate (50mg)Celon Lab
Imutrex 10mg TabletMethotrexate (10mg)Cipla Ltd.
Imutrex 2.5mg TabletMethotrexate (2.5mg)Cipla Ltd.
Imutrex 30mg InjectionMethotrexate (30mg)Cipla Ltd.
Imutrex 7.5mg TabletMethotrexate (7.5mg)Cipla Ltd.
Oncotrex 10mg TabletMethotrexate (10mg)Sun Pharmaceutical Industries Ltd.
Oncotrex 2.5mg TabletMethotrexate (2.5mg)Sun Pharmaceutical Industries Ltd.
Oncotrex 5mg TabletMethotrexate (5mg)Sun Pharmaceutical Industries Ltd.
Oncotrex 7.5mg TabletMethotrexate (7.5mg)Sun Pharmaceutical Industries Ltd.
Unitrexate 500/20ML InjectionMethotrexate (500/20ML)United Biotech
UNITREXATE 50mg InjectionMethotrexate (50mg)United Biotech
Zexate 15mg InjectionMethotrexate (15mg)Fresenius Kabi pharmaceuticals
Zexate 2.5mg TabletMethotrexate (2.5mg)Fresenius Kabi pharmaceuticals
Zexate 500mg InjectionMethotrexate (500mg)Fresenius Kabi pharmaceuticals
Zexate 50mg InjectionMethotrexate (50mg)Fresenius Kabi pharmaceuticals
Aiitrex 25mg TabletMethotrexate (25mg)Naprod Life Sciencesstrip of 10 tablets
Alltrex 2.5mg TabletMethotrexate (2.5mg)Miracalus Pharma Pvt Ltdstrip of 10 tablets
Alltrex 50mg InjectionMethotrexate (50mg)Miracalus Pharma Pvt Ltdvial of 2 ml Injection
B Trax 1000mg InjectionMethotrexate (1000mg)Health Biotech Limitedvial of 10 ml Injection
Beltrax 5mg TabletMethotrexate (5mg)Blubell Pharmastrip of 10 tablets
Biotrexate 1000mg InjectionMethotrexate (1000mg)Biochem Pharmaceutical Industriesvial of 1 Injection
Biotrexate 15mg InjectionMethotrexate (15mg)Biochem Pharmaceutical Industriesvial of 1 Injection
Biotrexate 500mg InjectionMethotrexate (500mg)Biochem Pharmaceutical Industriesvial of 1 Injection
Biotrexate 50mg InjectionMethotrexate (50mg)Biochem Pharmaceutical Industriesvial of 2 ml Injection
Caditrex 50mg InjectionMethotrexate (50mg)Cadila Pharmaceuticals Ltdvial of 1 Injection
Cytotrex 2.5mg TabletMethotrexate (2.5mg)BDH Industries Ltdstrip of 10 tablets
DavaIndia Methotrexate 5mg TabletMethotrexate (5mg)Davaindia Generic Pharmacystrip of 10 tablets
DavaIndia Methotrexate 7.5mg TabletMethotrexate (7.5mg)Davaindia Generic Pharmacystrip of 10 tablets
Dermatrax 7.5mg TabletMethotrexate (7.5mg)Galcare Pharmaceutical Pvt Ltdstrip of 10 tablets

Showing 30 of 180 catalog products. Search the full catalog in the app.

Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from light. After first puncture, store multiple-dose vials at 2°C to 8°C, and use within 30 days. Methotrexate Injection is a hazardous drug. Follow applicable special handling and disposal procedures.

Storage information from the U.S. FDA-approved label.

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+ Safety information

This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.

NepalDoc — Nepal's Healthcare Super-App (Beta) / नेपालको स्वास्थ्य सुपर-एप (बेटा).
Medicine information only — not medical advice. Confirm with a pharmacist or doctor.