Neostigmine

DOSAGE AND ADMINISTRATION Should be administered by trained healthcare providers Peripheral nerve stimulator and monitoring for twitch responses should be used to determine when Neostigmine Methylsulfate Injection, USP should be initiated and if additional doses are needed For reversal of NMBAs with shorter half-lives, when first twitch response is substantially greater than 10% of baseline…

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

CONTRAINDICATIONS Neostigmine Methylsulfate Injection, USP is contraindicated in patients with: known hypersensitivity to neostigmine methylsulfate (known hypersensitivity reactions have included urticaria, angioedema, erythema multiforme, generalized rash, facial swelling, peripheral edema, pyrexia, flushing, hypotension, bronchospasm, bradycardia and anaphylaxis). peritonitis or mechanical obstruction of the intestinal or urinary tract. Hypersensitivity to neostigmine Peritonitis or mechanical obstruction of the intestinal or urinary tract

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

WARNINGS AND PRECAUTIONS Bradycardia: Atropine or glycopyrrolate should be administered prior to Neostigmine Methylsulfate Injection, USP to lessen risk of bradycardia. Serious Reactions with Coexisting Conditions: Use with caution in patients with coronary artery disease, cardiac arrhythmias, recent acute coronary syndrome or myasthenia gravis. Neuromuscular Dysfunction: Can occur if large doses of Neostigmine Methylsulfate Injection, USP are administered when neuromuscular blockade is minimal; reduce dose if recovery from neuromuscular blockade is nearly complete.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

6. ADVERSE REACTIONS Most common adverse reactions during treatment: bradycardia, nausea and vomiting. To report SUSPECTED ADVERSE REACTIONS, contact Hikma Pharmaceuticals USA Inc. at 1-877-845-0689, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1.

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

13 products from 7 makers in the NepalDoc medicine catalog use this generic:

Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Stored at 20° to 25°C (68° to 77°F); Protect from light.

Storage information from the U.S. FDA-approved label.