1.1 Treatment of Hypoprothrombinemia Due to Vitamin K Deficiency or Interference Phytonadione Injectable Emulsion, USP is indicated for the treatment of the following coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity; anticoagulant-induced hypoprothrombinemia caused by coumarin or indanedione derivatives…
From the U.S. FDA-approved label for Phytomenadione. Full label: DailyMed.
1.1 Treatment of Hypoprothrombinemia Due to Vitamin K Deficiency or Interference Phytonadione Injectable Emulsion, USP is indicated for the treatment of the following coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity; anticoagulant-induced hypoprothrombinemia caused by coumarin or indanedione derivatives; hypoprothrombinemia due to antibacterial therapy; hypoprothrombinemia secondary to factors limiting absorption or synthesis of vitamin K, e.g., obstructive jaundice, biliary fistula, sprue, ulcerative colitis, celiac disease, intestinal resection, cystic fibrosis of the pancreas, and regional enteritis; other drug-induced hypoprothrombinemia where it is definitely shown that the result is due to interference with vitamin K metabolism, e.g., salicylates. 1.2 Prophylaxis and Treatment of Vitamin K-Deficiency Bleeding in Neonates Phytonadione Injectable Emulsion, USP is indicated for prophylaxis and treatment of vitamin K-deficiency bleeding in neonates.
From the U.S. FDA-approved label for Phytomenadione. Full label: DailyMed.
2.1 Dosing Considerations Whenever possible, administer Phytonadione Injectable Emulsion, USP by the subcutaneous route. When intravenous administration is unavoidable, inject the drug very slowly, not exceeding 1 mg per minute. Monitor international normalized ratio (INR) regularly and as clinical conditions indicate.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Hypersensitivity to phytonadione or any other component of this medication. Hypersensitivity to any component of this medication.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
5.1 Hypersensitivity Reactions Fatal and severe hypersensitivity reactions, including anaphylaxis, have occurred with intravenous or intramuscular administration of Phytonadione Injectable Emulsion. Reactions have occurred despite dilution to avoid rapid intravenous infusion and upon first dose. These reactions have included shock, cardiorespiratory arrest, flushing, diaphoresis, chest pain, tachycardia, cyanosis, weakness, and dyspnea. Administer Phytonadione Injectable Emulsion subcutaneously whenever feasible.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
The following serious adverse reactions are described elsewhere in the labeling: Hypersensitivity Reactions, Cutaneous Reactions 6.1 Clinical Trials and Post-Marketing Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed…
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
20 products from 15 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| K TAB 5mg Tablet | Phytomenadione (Vitamin K1) | Asian Pharmaceuticals Pvt. Ltd. | |
| KONAKION 10mg Injection | Phytomenadione (Vitamin K1) | ROCHE Pharma | |
| Govit-K Injection | Phytomenadione (1mg) | H & I Critical Care | ampoule of 0.5 ml Injection |
| Injek 10mg Injection | Phytomenadione (10mg) | Neon Laboratories Ltd | vial of 1 ml Injection |
| Injek 1mg Injection | Phytomenadione (1mg) | Neon Laboratories Ltd | vial of 1 ml Injection |
| K-NAT Injection | Vitamin K (1mg) | Kontest Chemicals Ltd | vial of 1 ml Injection |
| K-Win 10mg Injection | Phytomenadione (10mg) | Mercury Laboratories Ltd | vial of 1 ml Injection |
| Kenadion 10mg Injection | Vitamin K (10mg) | Samarth Life Sciences Pvt Ltd | vial of 1 ml Injection |
| Kenadion 1mg Injection 0.5 ml | Phytomenadione (1mg) | Samarth Life Sciences Pvt Ltd | vial of 1 Injection |
| Kenadion 1mg Tablet | Phytomenadione (1mg) | Samarth Life Sciences Pvt Ltd | strip of 10 tablets |
| Kip 10mg Injection | Phytomenadione (10mg) | DWD Pharmaceuticals Ltd | vial of 1 ml Injection |
| Kip 1mg Injection | Phytomenadione (1mg) | DWD Pharmaceuticals Ltd | vial of 1 ml Injection |
| Klot 10mg Injection | Vitamin K (10mg) | Tribhawan Injectables | vial of 1 ml Injection |
| Kvi 1mg Injection | Phytomenadione (1mg) | Dewcare Concept Pvt.Ltd. | vial of 1 ml Injection |
| Neo K 1mg Injection | Vitamin K (1mg) | Lincoln Pharmaceuticals Ltd | vial of 1 ml Injection |
| Phyto K1 1mg Injection | Phytomenadione (1mg) | Delvin Formulations Pvt Ltd | vial of 1 ml Injection |
| Phyto K1 5mg Tablet | Phytomenadione (5mg) | Delvin Formulations Pvt Ltd | strip of 10 tablets |
| Vit K 1mg Injection | Phytomenadione (1mg) | Suncure Lifescience Pvt Ltd | vial of 0.5 ml Injection |
| Vitadione 10mg Injection | Phytomenadione (10mg) | Casca Remedies Pvt Ltd | vial of 1 ml Injection |
| Weldion 1mg Injection | Phytomenadione (1mg) | Welgenic Pharma | vial of 0.5 ml Injection |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store at 20° to 25°C (68° to 77°F); Protect Phytonadione Injectable Emulsion, USP from light.
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
