PROTOPAM Chloride is indicated as an antidote: in the treatment of poisoning due to those pesticides and chemicals (e.g., nerve agents) of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis. The principal indications for the use of PROTOPAM Chloride are muscle weakness and respiratory depression.
From the U.S. FDA-approved label for Pralidoxime. Full label: DailyMed.
PROTOPAM Chloride is indicated as an antidote: in the treatment of poisoning due to those pesticides and chemicals (e.g., nerve agents) of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis. The principal indications for the use of PROTOPAM Chloride are muscle weakness and respiratory depression. In severe poisoning, respiratory depression may be due to muscle weakness.
From the U.S. FDA-approved label for Pralidoxime. Full label: DailyMed.
Organophosphate Poisoning Treatment should include general supportive care, atropinization, and decontamination, in addition to the use of PROTOPAM Chloride. Treatment is most effective if initiated immediately after poisoning. Administration of PROTOPAM Chloride should be carried out slowly and, preferably, by infusion.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
There are no known absolute contraindications for the use of PROTOPAM Chloride (see PRECAUTIONS, Drug Interactions and DOSAGE AND ADMINISTRATION ). Relative contraindications include known hypersensitivity to the drug and other situations in which the risk of its use clearly outweighs possible benefit.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
PROTOPAM Chloride is not effective in the treatment of poisoning due to phosphorus, inorganic phosphates, or organophosphates not having anticholinesterase activity. PROTOPAM Chloride is not indicated as an antidote for intoxication by pesticides of the carbamate class since it may increase the toxicity of carbaryl.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
Forty to 60 minutes after intramuscular injection, mild to moderate pain may be experienced at the site of injection. Pralidoxime chloride may cause blurred vision, diplopia and impaired accommodation, dizziness, headache, drowsiness, nausea, tachycardia, increased systolic and diastolic blood pressure, hyperventilation, and muscular weakness when given parenterally to normal volunteers who have not been exposed to…
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
19 products from 14 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Adipam 25mg Injection | Pralidoxime (25mg/ml) | Adison Laboratories | vial of 20 ml Injection |
| Aldopam 500mg Injection | Pralidoxime (500mg) | Samarth Life Sciences Pvt Ltd | vial of 20 ml Injection |
| Aquapam Injection | Pralidoxime (25mg/ml) | Aqua Fina Injecta Pvt Ltd | vial of 20 ml Injection |
| Biopam 500mg Injection | Pralidoxime (500mg) | Qantas Biopharma Private Limited | vial of 20 ml Injection |
| Cbc Pam 500mg Injection | Pralidoxime (500mg) | Chandra Bhagat Pharma Pvt Ltd | vial of 20 ml Injection |
| Clopam 1gm Injection | Pralidoxime (1gm) | Chandra Bhagat Pharma Pvt Ltd | vial of 20 ml Injection |
| Clopam 500mg Injection | Pralidoxime (500mg) | Chandra Bhagat Pharma Pvt Ltd | vial of 1 Injection |
| Connectpam Injection | Pralidoxime (500mg) | Connect Life Pharma Pvt Ltd | ampoule of 20 ml Injection |
| Elpam Injection | Pralidoxime (500mg) | Lichem Pharmaceuticals | ampoule of 20 ml Injection |
| Lyphe 1gm Injection | Pralidoxime (1gm) | Vhb Life Sciences Inc | vial of 1 Injection |
| Neopam 25mg Injection | Pralidoxime (25mg) | Troikaa Pharmaceuticals Ltd | vial of 2 ml Injection |
| Neopam 500mg Injection | Pralidoxime (500mg) | Troikaa Pharmaceuticals Ltd | vial of 20 ml Injection |
| Pam 500mg Injection | Pralidoxime (500mg) | Acme Pharmaceutical | vial of 20 ml Injection |
| Pam Up 500mg Injection | Pralidoxime (500mg) | Redson Laboratories Pvt Ltd | vial of 20 ml Injection |
| Purepam Injection | Pralidoxime (25mg/ml) | Nucleus Incorporation | vial of 20 ml Injection |
| Redpam 25mg Injection | Pralidoxime (25mg) | Redson Laboratories Pvt Ltd | vial of 20 ml Injection |
| Unipam 1gm Injection | Pralidoxime (1gm) | Vhb Life Sciences Inc | vial of 1 Injection |
| V-Pam Injection | Pralidoxime (500mg) | Vulcan Laboratories Pvt Ltd | ampoule of 20 ml Injection |
| ZED-PAM 500mg Injection | Pralidoxime (500mg) | PCI Pharmaceuticals | ampoule of 20 ml Injection |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store at 20°-25°C (68°-77°F), excursions permitted to 15°-30°C (59°-86°F).
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
