SOVALDI is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of: Adult patients with genotype 1, 2, 3 or 4 chronic HCV infection without cirrhosis or with compensated cirrhosis as a component of a combination antiviral treatment regimen. Pediatric patients 3 years of age and older with genotype 2 or 3 chronic HCV infection without cirrhosis or with compensated cirrhosis in combination with ribavirin.
From the U.S. FDA-approved label for Sofosbuvir. Full label: DailyMed.
SOVALDI is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of: Adult patients with genotype 1, 2, 3 or 4 chronic HCV infection without cirrhosis or with compensated cirrhosis as a component of a combination antiviral treatment regimen. Pediatric patients 3 years of age and older with genotype 2 or 3 chronic HCV infection without cirrhosis or with compensated cirrhosis in combination with ribavirin.
From the U.S. FDA-approved label for Sofosbuvir. Full label: DailyMed.
Testing Prior to the Initiation of Therapy: Test all patients for HBV infection by measuring HBsAg and anti-HBc. Recommended dosage in adults: One 400 mg tablet taken once daily with or without food. Recommended dosage in pediatric patients 3 years of age and older: Recommended dosage of SOVALDI in pediatric patients 3 years of age and older with genotype 2 or 3 HCV using SOVALDI tablets or oral pellets is based on weight.
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
When SOVALDI is used in combination with ribavirin or peginterferon alfa/ribavirin, the contraindications applicable to those agents are applicable to combination therapies. Refer to the prescribing information of peginterferon alfa and ribavirin for a list of their contraindications. When used in combination with peginterferon alfa/ribavirin or ribavirin alone, all contraindications to peginterferon alfa and/or ribavirin also apply to SOVALDI combination therapy.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
Risk of Hepatitis B Virus Reactivation: Test all patients for evidence of current or prior HBV infection before initiation of HCV treatment. Monitor HCV/HBV coinfected patients for HBV reactivation and hepatitis flare during HCV treatment and post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
The following serious adverse reactions are described below and elsewhere in the labeling: Serious Symptomatic Bradycardia When Coadministered with Amiodarone. The most common adverse events (incidence greater than or equal to 20%, all grades) observed with SOVALDI in combination with ribavirin were fatigue and headache.
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
17 products from 16 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Hepcivir 400mg Tablet | Sofosbuvir (400mg) | Asian Pharmaceuticals Pvt. Ltd. | |
| Sofovir 400mg Tablet | Sofosbuvir (400mg) | Hetero Drugs Ltd. | |
| Sofuvir 400mg Tablet | Sofosbuvir (400mg) | Magnus Pharma Pvt. Ltd. | |
| Cimivir 400mg Tablet | Sofosbuvir (400mg) | Biocon | strip of 28 tablets |
| Hepcinat Tablet | Sofosbuvir (400mg) | Natco Pharma Ltd | strip of 28 tablets |
| Hepcvir 400mg Tablet | Sofosbuvir (400mg) | Cipla Ltd | strip of 28 tablets |
| MY Hep 400mg Tablet | Sofosbuvir (400mg) | Mylan Pharmaceuticals Pvt Ltd | strip of 28 tablets |
| Novisof 400mg Tablet | Sofosbuvir (400mg) | Wockhardt Ltd | strip of 28 tablets |
| Resof 400mg Tablet | Sofosbuvir (400mg) | Dr Reddy's Laboratories Ltd | strip of 28 tablets |
| Sofab 400mg Tablet | Sofosbuvir (400mg) | Sun Pharmaceutical Industries Ltd | strip of 28 tablets |
| Sofcivir Tablet | Sofosbuvir (400mg) | Chemo Healthcare Pvt Ltd | bottle of 28 tablets |
| Sofocruz 400mg Tablet | Sofosbuvir (400mg) | Torrent Pharmaceuticals Ltd | strip of 28 tablets |
| Sofocure Tablet | Sofosbuvir (400mg) | Emcure Pharmaceuticals Ltd | strip of 10 tablets |
| Sofokem 400mg Tablet | Sofosbuvir (400mg) | Alkem Laboratories Ltd | strip of 28 tablets |
| Sovaldi 400mg Tablet | Sofosbuvir (400mg) | Mylan Pharmaceuticals Pvt Ltd | bottle of 28 tablets |
| Sovihep 400mg Tablet | Sofosbuvir (400mg) | Zydus Cadila | strip of 28 tablets |
| Virso Tablet | Sofosbuvir (400mg) | Strides shasun Ltd | bottle of 28 tablets |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store below 30 °C (86 °F). Dispense only in original container Do not use if seal over bottle opening is broken or missing
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
