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Spironolactone

Aldosterone antagonist
Tablet12.5 mg · 25 mg · 100 mg35 brands · 17 makers
Spironolactone is an aldosterone antagonist. Spironolactone is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure., Use as an add-on therapy for the treatment of hypertension, to lower blood pressure. Spironolactone is listed in Nepal's National List of Essential Medicines (NLEM, Sixth Revision 2021) under Cardiovascular Medicines.
Generic namespironolactone
Therapeutic classCardiovascular Medicines > 12.4 Medicines used in heart failure
Therapeutic classDiuretics
Form & strength (NLEM)Tablet: 12.5 mg 25 mg
Form & strength (NLEM)Tablet:25 mg, 100 mg
Source / स्रोतNational List of Essential Medicines Nepal (2021); NepalDoc medicine catalog

What it's for

Spironolactone is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure., Use as an add-on therapy for the treatment of hypertension, to lower blood pressure.

From the U.S. FDA-approved label for Spironolactone. Full label: DailyMed.

Spironolactone is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure., Use as an add-on therapy for the treatment of hypertension, to lower blood pressure.

From the U.S. FDA-approved label for Spironolactone. Full label: DailyMed.

Heart Failure: Initiate treatment at 25 mg once daily., Hypertension: Initiate treatment at 25 mg to 100 mg daily in either single or divided doses., Edema: Initiate therapy in a hospital setting and titrate slowly. The recommended initial daily dose is 100 mg in single or divided doses., Primary hyperaldosteronism: Initiate treatment at 100 mg to 400 mg in preparation for surgery. In patients unsuitable for surgery use the lowest effective dosage determined for the individual patient.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Spironolactone tablets are contraindicated in the patients with: Hyperkalemia, Addison's disease, Concomitant use of eplerenone Spironolactone tablets are contraindicated in patients with: Hyperkalemia, Addison's disease, Concomitant use of eplerenone

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Hyperkalemia: Monitor serum potassium within one week of initiation and regularly thereafter., Hypotension and Worsening Renal Function: Monitor volume status and renal function periodically., Electrolyte and Metabolic Abnormalities: Monitor serum electrolytes, uric acid and blood glucose periodically., Gynecomastia: Spironolactone can cause gynecomastia. 5.1 Hyperkalemia Spironolactone can cause hyperkalemia.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The following clinically significant adverse reactions are described elsewhere in the labeling: Hyperkalemia, Hypotension and Worsening Renal Function, Electrolyte and Metabolic Abnormalities, Gynecomastia, Impaired neurological function/ coma in patients with hepatic impairment, cirrhosis and ascites The following adverse reactions associated with the use of spironolactone were identified in clinical trials or postmarketing…

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

35 products from 17 makers in the NepalDoc medicine catalog use this generic:

BrandCompositionMakerPack
Aldace 100 100mg TabletSpironolactone (100mg)Omnica Laboratories Pvt. Ltd..
Aldace 25 25mg TabletSpironolactone (25mg)Omnica Laboratories Pvt. Ltd..
Aldactone 100 100mg TabletSpironolactone (100mg)RPG Life Sciences Ltd.
Aldactone 25 25mg TabletSpironolactone (25mg)RPG Life Sciences Ltd.
Ema 25mg TabletSpironolactone (25mg)Quest Pharmaceuticals Pvt. Ltd.
Ema 50mg TabletSpironolactone (50mg)Quest Pharmaceuticals Pvt. Ltd.
Rosetone 100mg TabletSpironolactone (100mg)CTL Pharmaceuticals Pvt. Ltd.
Rosetone 12.5mg TabletSpironolactone (12.5mg)CTL Pharmaceuticals Pvt. Ltd.
Rosetone 25mg TabletSpironolactone (25mg)CTL Pharmaceuticals Pvt. Ltd.
Rosetone 50mg TabletSpironolactone (50mg)CTL Pharmaceuticals Pvt. Ltd.
Spilac 25mg TabletSpironolactone (25mg)Biogain Remedies Pvt. Ltd.
Spilac 50mg TabletSpironolactone (50mg)Biogain Remedies Pvt. Ltd.
Spirolac 12.5 12.5mg TabletSpironolactone (12.5mg)National Healthcare Pvt. Ltd.
Spirolac 25 25mg TabletSpironolactone (25mg)National Healthcare Pvt. Ltd.
Spril 100 100mg TabletSpironolactone (100mg)Lomus Pharmaceutical Pvt. Ltd.
Spril 25 25mg TabletSpironolactone (25mg)Lomus Pharmaceutical Pvt. Ltd.
Aldace 25mg TabletSpironolactone (25mg)Omnica Laboratoriesstrip of 10 tablets
Aldactone 100 TabletSpironolactone (100mg)RPG Life Sciences Ltdstrip of 15 tablets
Aldactone 50 TabletSpironolactone (50mg)RPG Life Sciences Ltdstrip of 15 tablets
Aldactone TabletSpironolactone (25mg)RPG Life Sciences Ltdstrip of 15 tablets
Aldotone 50mg TabletSpironolactone (50mg)Samarth Life Sciences Pvt Ltdstrip of 15 tablets
Cglactone 100mg TabletSpironolactone (100mg)Cmg Biotech Pvt Ltdstrip of 10 tablets
Cglactone 25mg TabletSpironolactone (25mg)Cmg Biotech Pvt Ltdstrip of 10 tablets
Cglactone 50mg TabletSpironolactone (50mg)Cmg Biotech Pvt Ltdstrip of 10 tablets
Edeflow 100 TabletSpironolactone (100mg)Leeford Healthcare Ltdstrip of 10 tablets
Edeflow 50 TabletSpironolactone (50mg)Leeford Healthcare Ltdstrip of 10 tablets
Genericart Spironolactone 25mg TabletSpironolactone (25mg)Swast Aushadhi Seva Generic Medicine Storestrip of 10 tablets
Lactone 100mg TabletSpironolactone (100mg)Aimil Pharmaceuticals India Ltdstrip of 6 tablets
Silectone 100 TabletSpironolactone (100mg)Johnlee Pharmaceuticals Pvt Ltdstrip of 10 tablets
Silectone 25 TabletSpironolactone (25mg)Johnlee Pharmaceuticals Pvt Ltdstrip of 10 tablets

Showing 30 of 35 catalog products. Search the full catalog in the app.

Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Keep this and all drugs out of the reach of children. Storage Store at 20° to 25°C (68° to 77°F). Protect from light.

Storage information from the U.S. FDA-approved label.

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+ Safety information

This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.

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Medicine information only — not medical advice. Confirm with a pharmacist or doctor.