Valproic acid (sodium valproate)

Valproic acid oral solution is intended for oral administration. Simple and Complex Absence Seizures: Start at 10 to 15 mg/kg/day, increasing at 1 week intervals by 5 to 10 mg/kg/week until seizure control or limiting side effects Safety of doses above 60 mg/kg/day is not established 2.1 Epilepsy Valproic acid oral solution is intended for oral administration. Patients should be informed to take valproic acid oral solution every day as prescribed.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Valproic acid should not be administered to patients with hepatic disease or significant hepatic dysfunction. Valproic acid is contraindicated in patients known to have mitochondrial disorders caused by mutations in mitochondrial DNA polymerase γ (POLG; e.g., Alpers-Huttenlocher Syndrome) and children under two years of age who are suspected of having a POLG-related disorder. Valproic acid is contraindicated in patients with known hypersensitivity to the drug. Valproic acid is contraindicated in patients with known urea cycle disorders.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Hepatotoxicity; evaluate high risk populations and monitor serum liver tests Birth defects, decreased IQ, and neurodevelopmental disorders following in utero exposure; should not be used to treat women with epilepsy or bipolar disorder who are pregnant or who plan to become pregnant or to treat a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The following serious adverse reactions are described below and elsewhere in the labeling: Hepatic failure Birth defects Decreased IQ following in utero exposure Pancreatitis Hyperammonemic encephalopathy Suicidal behavior and ideation Bleeding and other hematopoietic disorders Hypothermia Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multiorgan hypersensitivity reactions Because clinical studies are conducted…

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

224 products from 97 makers in the NepalDoc medicine catalog use this generic:

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Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Store at 20° to 25°C (68° to 77°F).

Storage information from the U.S. FDA-approved label.