Vinblastine Sulfate Injection is indicated in the palliative treatment of the following: I. Frequently Responsive Malignancies, Generalized Hodgkin’s disease (Stages III and IV, Ann Arbor modification of Rye staging system), Lymphocytic lymphoma (nodular and diffuse, poorly and well differentiated), Histiocytic lymphoma, Mycosis fungoides (advanced stages), Advanced carcinoma of the testis, Kaposi’s sarcoma, Letterer-Siwe disease (histiocytosis X) II.
From the U.S. FDA-approved label for Vinblastine. Full label: DailyMed.
Vinblastine Sulfate Injection is indicated in the palliative treatment of the following: I. Frequently Responsive Malignancies, Generalized Hodgkin’s disease (Stages III and IV, Ann Arbor modification of Rye staging system), Lymphocytic lymphoma (nodular and diffuse, poorly and well differentiated), Histiocytic lymphoma, Mycosis fungoides (advanced stages), Advanced carcinoma of the testis, Kaposi’s sarcoma, Letterer-Siwe disease (histiocytosis X) II. Less Frequently Responsive Malignancies, Choriocarcinoma resistant to other chemotherapeutic agents, Carcinoma of the breast, unresponsive to appropriate endocrine surgery and hormonal therapy Current principles of chemotherapy for many types of cancer include the concurrent administration of several antineoplastic agents. For enhanced therapeutic effect without additive toxicity, agents with different dose-limiting clinical toxicities and different mechanisms of action are generally selected. Therefore, although vinblastine sulfate is effective as a single agent in the aforementioned indications, it is usually administered in combination with other antineoplastic drugs. Such combination therapy produces a greater percentage of response than does a single-agent regimen.
From the U.S. FDA-approved label for Vinblastine. Full label: DailyMed.
This preparation is for intravenous use only (see WARNINGS ). Special Dispensing Information - To reduce the potential for fatal medication errors due to incorrect route of administration, vinblastine sulfate injection should be diluted in a flexible plastic container and prominently labeled (as indicated), “FOR INTRAVENOUS USE ONLY – FATAL IF GIVEN BY OTHER ROUTES.” (see WARNINGS ).
Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.
Vinblastine sulfate is contraindicated in patients who have significant granulocytopenia unless this is a result of the disease being treated. It should not be used in the presence of bacterial infections. Such infections must be brought under control prior to the initiation of therapy with vinblastine sulfate.
Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.
This preparation is for intravenous use only. It should be administered by individuals experienced in the administration of vinblastine sulfate. The intrathecal administration of vinblastine sulfate usually results in death.
Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.
Prior to the use of the drug, patients should be advised of the possibility of untoward symptoms. In general, the incidence of adverse reactions attending the use of vinblastine sulfate appears to be related to the size of the dose employed. With the exception of epilation, leukopenia and neurologic side effects, adverse reactions generally have not persisted for longer than 24 hours. Neurologic side effects are not common;
Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.
6 products from 5 makers in the NepalDoc medicine catalog use this generic:
| Brand | Composition | Maker | Pack |
|---|---|---|---|
| Cytoblastin 10ml Injection | Vinblastine (10ml) | Cipla Ltd. | |
| Vinblastine 10mg Injection | Vinblastine (10mg) | Cipla Ltd. | |
| Hoydetain 1mg Injection | Vinblastine (1mg) | Taj Pharma India Ltd | vial of 10 ml Powder for Injection |
| Kristina V 1mg Injection | Vinblastine (1mg) | Khandelwal Laboratories Pvt Ltd | vial of 1 Injection |
| Uniblastin 10mg Injection | Vinblastine (10mg) | United Biotech Pvt Ltd | vial of 10 ml Injection |
| Vblastin 10mg Injection | Vinblastine (10mg) | Chandra Bhagat Pharma Pvt Ltd | vial of 10 ml Injection |
Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.
Store products in refrigerator 2° to 8°C (36° to 46°F) to assure extended stability. PROTECT FROM LIGHT.
Storage information from the U.S. FDA-approved label.
This page is information only and is not medical advice. Medicine details come from the sources listed above and may change — always confirm the medicine, strength and dose with a pharmacist or doctor before use. NLEM listing does not guarantee that a medicine is in stock at any pharmacy.
