Ramipril

Hypertension: Initial dose is 2.5 mg to 20 mg once daily. Adjust dosage according to blood pressure response after 2 to 4 weeks of treatment. The usual maintenance dose following titration is 2.5 mg to 20 mg daily as a single dose or equally divided doses.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Ramipril capsules are contraindicated in patients who are hypersensitive to this product or any other ACE inhibitor (e.g., a patient who has experienced angioedema during therapy with any other ACE inhibitor). Ramipril capsules are contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). Do not administer ramipril capsules within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Angioedema, increased risk in patients with a prior history Hypotension and hyperkalemia Renal impairment: monitor renal function during therapy Avoid concomitant use of an ACE inhibitor and angiotensin blocker Rare cholestatic jaundice and hepatic failure Rare neutropenia and agranulocytosis 5.1 Anaphylactoid and Possibly Related Reactions Presumably because drugs that act directly on the renin-angiotensin-aldosterone system (e.g., ACE inhibitors) affect the metabolism of eicosanoids and polypeptides, including endogenous bradykinin, patients receiving these drugs (including ramipril) may be subject to a variety of adverse reactions, some of them serious.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The most common adverse reactions in patients with hypertension included headache, dizziness, fatigue, and cough. To report SUSPECTED ADVERSE REACTIONS, contact Zydus Pharmaceuticals (USA) Inc.

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

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Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.