Efavirenz (EFV or EFZ)

Efavirenz capsules should be taken orally once daily on an empty stomach, preferably at bedtime. Recommended adult dose: 600 mg. With voriconazole, increase voriconazole maintenance dose to 400 mg every 12 hours and decrease efavirenz dose to 300 mg once daily using the capsule formulation.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Efavirenz capsules are contraindicated in patients with previously demonstrated clinically significant hypersensitivity (e.g., Stevens-Johnson syndrome, erythema multiforme, or toxic skin eruptions) to any of the components of this product. Coadministration of efavirenz with elbasvir and grazoprevir is contraindicated. Patients with previously demonstrated hypersensitivity (e.g., Stevens-Johnson syndrome, erythema multiforme, or toxic skin eruptions) to any of the components of this product. Coadministration of efavirenz with elbasvir/grazoprevir.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

QTc prolongation: Consider alternatives to efavirenz in patients taking other medications with a known risk of Torsade de Pointes or in patients at higher risk of Torsade de Pointes. Do not use as a single agent or add on as a sole agent to a failing regimen. Consider potential for cross-resistance when choosing other agents. Not recommended with ATRIPLA, which contains efavirenz, emtricitabine, and tenofovir disoproxil fumarate, unless needed for dose adjustment when coadministered with rifampin.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The most significant adverse reactions observed in patients treated with efavirenz are: psychiatric symptoms nervous system symptoms rash hepatotoxicity Most common adverse reactions (>5%, moderate-severe) are impaired concentration, abnormal dreams, rash, dizziness, nausea, headache, fatigue, insomnia, and vomiting. To report SUSPECTED ADVERSE REACTIONS, contact Aurobindo Pharma USA, Inc.

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

16 products from 11 makers in the NepalDoc medicine catalog use this generic:

Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Storage Efavirenz capsules should be stored at 20° to 25°C (68° to 77°F);

Storage information from the U.S. FDA-approved label.