Nevirapine (NVP)

If any patient experiences rash during the 14-day lead-in period, do not increase dose until the rash has resolved. 2.1 Adults The recommended dose for Nevirapine tablets, USP is one 200 mg tablet daily for the first 14 days, followed by one 200 mg tablet twice daily, in combination with other antiretroviral agents. The lead-in period has been observed to decrease the incidence of rash.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Patients with moderate or severe (Child-Pugh Class B or C, respectively) hepatic impairment Use as part of occupational and non-occupational post-exposure prophylaxis (PEP) regimens, an unapproved use 4.1 Hepatic Impairment Nevirapine, USP is contraindicated in patients with moderate or severe (Child-Pugh Class B or C, respectively) hepatic impairment. 4.2 Post-Exposure Prophylaxis Nevirapine, USP is contraindicated for use as part of occupational and non-occupational post-exposure prophylaxis (PEP) regimens.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

The most serious adverse reactions associated with Nevirapine are hepatitis/hepatic failure, Stevens-Johnson syndrome, toxic epidermal necrolysis, and hypersensitivity reactions. Hepatitis/hepatic failure may be associated with signs of hypersensitivity which can include severe rash or rash accompanied by fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, facial edema, eosinophilia, granulocytopenia, lymphadenopathy, or renal dysfunction.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The most common adverse reaction is rash. In adults the incidence of rash is 15% vs 6% with placebo, with Grade 3/4 rash occurring in 2% of subjects In pediatric subjects the incidence of rash (all causality) was 21% To report SUSPECTED ADVERSE REACTIONS, contact Amneal Pharmaceuticals at 1-877-835-5472 or www.amneal.com or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

11 products from 8 makers in the NepalDoc medicine catalog use this generic:

Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Storage Store below 30 ° C. Protect from light. Store in a safe place out of the reach of children.

Storage information from the U.S. FDA-approved label.