Paroxetine

Swallow tablet whole; do not chew or crush. Recommended starting and maximum daily dosage: Indication Starting Dose Maximum Dose MDD 25 mg/day 62.5 mg/day PD 12.5 mg/day 75 mg/day SAD 12.5 mg/day 37.5 mg/day PMDD 12.5 mg/day 25 mg/day For PMDD, dose continuously or intermittently (luteal phase only). If inadequate response to starting dosage, titrate in 12.5 mg per day increments once weekly.

Directions from the U.S. FDA-approved label — your doctor or pharmacist may advise differently.

Paroxetine HCL CR is contraindicated in patients: Taking, or within 14 days of stopping, MAOIs (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome. Paroxetine HCL CR should not be used in patients receiving medications that can prolong QT interval and are also metabolized by CYP450 2D6,such as thioridazine or pimozide. With known hypersensitivity (e.g., anaphylaxis, angioedema, Stevens-Johnson syndrome) to paroxetine or to any of the inactive ingredients in Paroxetine HCL CR.

Excerpt from the U.S. FDA-approved label. Talk to a pharmacist or doctor before use.

Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone. If occurs, discontinue Paroxetine HCL CR and serotonergic agents and initiate supportive measures. Embryofetal Toxicity: May cause fetal harm. Meta-analysis of epidemiological studies have shown increased risk (less than 2-fold) of cardiovascular malformations with exposure during the first trimester. Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulant drugs may increase risk.

Warnings and precautions excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor before use.

The following adverse reactions are included in more detail in other sections of the prescribing information: Hypersensitivity reactions to paroxetine Suicidal Thoughts and Behaviors Serotonin Syndrome Embryofetal and Neonatal Toxicity Increased Risk of Bleeding Activation of Mania/Hypomania Discontinuation Syndrome Seizures Angle-closure Glaucoma Hyponatremia Bone Fracture Sexual Dysfunction Most common adverse reactions…

Excerpt from the U.S. FDA-approved label — not a complete list. Talk to a pharmacist or doctor about side effects.

340 products from 156 makers in the NepalDoc medicine catalog use this generic:

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Brand list from the NepalDoc medicine catalog. Availability varies by pharmacy — call ahead to confirm stock.

Store at or below 25°C (77°F);.

Storage information from the U.S. FDA-approved label.